UK’s Sanders-Brown Researchers Discover Polyamines Prevent Collection of Alzheimer’s Disease Protein

UKNOW - University of Kentucky News - 6/7/2021
A study by several researchers at UK's Sanders-Brown Center on Aging (SBCoA) was recently highlighted in AlzForum. The study led by Daniel Lee, Ph.D., associate professor, UK Department of Neuroscience, and Maj-Linda Selenica, Ph.D., assistant professor, UK Department of Molecular & Cellular Biochemistry, found that polyamines prevent the clustering of a protein known as tau, which is a hallmark in Alzheimer’s disease.

University of Kentucky College of Medicine | Sanders-Brown Center on Aging

Alzheimer's Awareness Month Q&A with Dr. Daniel Lee - 12/3/2020
For Alzheimer’s Awareness Month, Dr. Lee discusses his research on Alzheimer’s disease and other neurodegenerative diseases, what inspired him to pursue a career in neuroscience, and what advice he has for the next generation of researchers.

Better Living Through Polyamines?

ALZFORUM News, Part 1 of 2 - 5/14/2021
Could primordial soup, semen, and rotting flesh hold clues to healthy cognitive aging? If the idea sounds a little repulsive, consider this. These three types of complex organic matter are all packed with polyamines—flat strings of amine groups that have been around since life began...

Polyamines–What Role in Neurodegeneration?

ALZFORUM News, Part 2 of 2 - 5/14/2021
Polyamines, the nitrogen-packed aliphatic molecules produced by our own cells and found in the foods we eat, have been cast by some as anti-aging dynamos. Studies suggest the compounds, most notably spermidine, counter cognitive slippage in animal models by revving up autophagy and mitochondrial function in the brain.