Citrullination

Summary:

Citrullination (citR), induced by peptidyl arginine deiminases (PADs), leads to an irreversible posttranslational modification (PTM) that alters protein structure/ function by neutralizing positively charged arginine residues within proteins. This conversion permanently alters the target by producing loss of positive charges and changes in protein stability. Reports show hypercitrullination in rheumatoid arthritis, Alzheimer’s disease, and cancer. We identified that tau and other disordered proteins become citrullinated. We aim to understand the role of citrullination during Alzheimer’s disease and related dementias.